Epidermis is the outermost layer of skin. And therefore receives almost all nutrition from diffused Oxygen.
It is almost 95% keratinocytes.
From inside to outside
First, Basement Membrane, just between dermis and epidermis - a funny, non-cellular layer
Stratum germinativum (where proliferation of keratinocytes happen). Attached to basement membrane by hemidesmosomes (antibodies against these cause bullous pemphigoid)
The spines of this layer is a result of desmosomes holding cell membranes together. The remaining part that are not held tight can shrink and therefore a thorny appearance comes about.
Acantholysis is the loss of this cohesion between epidermal cells. "Acantho-" stands for spiny or thorny. And "lysis" is breakdown as usual.
Antibodies against desmosome proteins (desmoglein 1 and 3) are the cause of Pemphigus Vulgaris
Nucleus lost, cytoplasm granular with leftovers.
Member of thick skin.